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Welcome to the Single Protein Mechanics and Engineering Lab!

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Everything in Biology is Mechanical

A new technique developed in the lab captures the regiospecific reaction of a cysteine residue with a disulfide bond. These reactions are central in many cellular processes, including oxidative folding. Our results have been published in Nature Chemistry in November, 2011. Also see the Nature Chemistry News and Views on the article by Chou and Buehler, and the highlight in Chemical and Engineering News.

Check out the upcoming 2012 Gordon Research Conference on "Single Molecule Approaches to Biology , Chaired by Julio and Stefan Hell and that serves as an interdisciplinary forum for some of the most innovative research in Biology.

Check out our recent preview on two Cell papers by Tania Baker´s group at MIT and Carlos Bustamante's group at Berkeley. Their results conclusively place the mechanical unfolding of proteins as a keystone in biology.

A new article published in Nature Structural & Molecular Biology by the Fernandez Lab shows the promise of paleoenzymology through the resurrection of four-billion-year-old enzymes. See the official press release as well as featured articles in Chemical & Engineering News, Science Daily and at NASA, Nature Methods and Thoughtomics.

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Julio Fernandez Lab, Phd Columbia University Biological Sciences MC 2449  1011A Fairchild Center  1212 Amsterdam Avenue  New York, N.Y. 10027  Phone: (212) 854 9474 ©2008 A Pannonica Production