Congratulations, Jorge, on the young biophysicist award from the Spanish Biophysical Society.
Have you ever wondered why stretching improves flexibility? Our new paper, to appear soon in Cell, describes the first mechanism that sustains mechanical memory in muscle cells. Yogis, stay alert for updates!
Our single molecule force-clamp AFM technique is now commercially available thanks to Luigs and Neumann. In contrast to other AFMs on the market, the new AFM is specifically built for operating in force-clamp mode. For more information, have a look at our recently published article in Nature Protocols.
In collaboration with the group of Jie Yan at the Mechanobiology Institute (Singapore), we have implemented covalent attachment using Halotag technology to pull from single proteins using Magnetic Tweezers (MT). Now, it is possible to study a single protein for days and with improved resolution at low forces. Single molecule AFM and MT techniques are a perfect combination to examine protein mechanobiochemistry. We will soon publish the reconstruction of the free energy of a protein under force, which will challenge classic views of protein dynamics.
Additional research areas in the lab include oxidative folding of virulence factors in bacteria (a follow-up of our 2012 paper in Cell) and the mechanical design of bacterial pili.